Comparison of the Sister Chromatid Exchange and Cell Survival Assays as a Measure of Tumor Cell Sensitivity in Vitro to c/s-Diamminedichloroplatinum (II)1
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چکیده
Cytotoxic effects of treating RIF-1, EMT6, and 9L tumor cell lines with c/s-diamminedichloroplatinum(ll) were measured with the sister chromatid exchange assay and compared to results obtained with the colony-forming efficiency assay. The greatest number of sister chromatid exchanges was induced in RIF-1 cells, fewer in EMT6 cells, and the least in 9L cells. Cell survival data obtained with the colony-forming efficiency assay paralleled data obtained with the sister chromatid exchange assay. These studies suggest that the sister chromatid exchange assay may be a useful method with which to determine the in vitro sensitivity of tumor cells to some antineoplastic agents.
منابع مشابه
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